Aldoc Gene Summary [Rat]
Enables fructose-bisphosphate aldolase activity and identical protein binding activity. Involved in animal organ regeneration and response to hypoxia. Located in axon. Is active in postsynaptic cytosol. Biomarker of borna disease and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system. Orthologous to human ALDOC (aldolase, fructose-bisphosphate C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aldoc |
| Official Name | aldolase, fructose-bisphosphate C [Source:RGD Symbol;Acc:2091] |
| Ensembl ID | ENSRNOG00000011452 |
| Bio databases IDs | |
| Aliases | aldolase, fructose-bisphosphate C |
| Synonyms | ALDC, ALDCAA, ALDO3, Aldolase 3, Aldolase C, aldolase C, fructose-bisphosphate, aldolase, fructose-bisphosphate C, F16dip7, Fructose bisphosphate aldolase c, RATALDCAA, SCRG2, Zebrin2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aldoc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- cytoskeletal protein binding
- TIM-like beta/alpha barrel domains
- Fructose-bisphosphate aldolase class-I
- fructose-bisphosphate aldolase
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Huntington disease
- organismal death
- schizophrenia
- glaucoma
- breast cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- Marfan syndrome
- pituitary gland adenoma
regulates
- UBE2N
- fructose-1,6-bisphosphate
- D-fructose
role in cell
- expression in
- proliferation
- apoptosis
- migration
- gluconeogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- organelle lumens
- cytoplasmic matrix
- cytosol
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aldoc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- gluconeogenesis
- glycolysis
- fructose metabolic process
- fructose 1,6-bisphosphate metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoskeleton
- cytosol
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytoskeletal protein binding
- fructose-bisphosphate aldolase activity