Pebp1 Gene Summary [Rat]
Enables ATP binding activity; mitogen-activated protein kinase binding activity; and receptor serine/threonine kinase binding activity. Involved in several processes, including positive regulation of acetylcholine biosynthetic process; positive regulation of mitotic nuclear division; and regulation of intracellular signal transduction. Located in several cellular components, including mitochondrial outer membrane; neuronal cell body; and synaptic vesicle. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PEBP1 (phosphatidylethanolamine binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pebp1 |
| Official Name | phosphatidylethanolamine binding protein 1 [Source:RGD Symbol;Acc:62017] |
| Ensembl ID | ENSRNOG00000001136 |
| Bio databases IDs | |
| Aliases | phosphatidylethanolamine binding protein 1 |
| Synonyms | HCNP, HCNPpp, HEL-210, HEL-S-34, HEL-S-96, LOC100506570, PBP, Pbp1, Pbpr, PEBP, Phosphatidylethanolamine-binding, phosphatidylethanolamine binding protein 1, RKIP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pebp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylethanolamine binding domain
- kinase binding
- lipid binding
- protein kinase binding
- phosphatidylethanolamine binding
- ATP binding
- enzyme binding
- protein binding
- receptor binding
- Phosphatidylethanolamine-binding protein
- PhosphatidylEthanolamine-Binding Protein (PEBP) domain
- mek binding domain
Pathways
Biological processes and signaling networks where the Pebp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- asthma
- septic shock
- heart failure
- experimentally-induced heart failure
- chronic sinusitis
- hepatitis B virus-related hepatocellular carcinoma
- androgenic alopecia
- aortic valve calcification
role in cell
- cell death
- proliferation
- phosphorylation in
- expression in
- apoptosis
- invasion
- activation in
- production in
- inhibition in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- dendrite tip
- cell surface
- cell borders
- Extracellular Space
- apical compartment
- cellular membrane
- Nucleus
- Plasma Membrane
- cytosol
- mitochondrial outer membrane
- dendritic spines
- synaptic vesicles
- perikaryon
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pebp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MAPK cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- serine-type endopeptidase inhibitor activity
- phosphatidylethanolamine binding
- protein binding
- RNA binding
- enzyme binding