Dguok Gene Summary [Rat]
Predicted to enable deoxyguanosine kinase activity. Involved in mitochondrial ATP synthesis coupled electron transport and negative regulation of neuron projection development. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Used to study mitochondrial DNA depletion syndrome 3. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 3; mitochondrial metabolism disease; and portal hypertension. Orthologous to human DGUOK (deoxyguanosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dguok |
| Official Name | deoxyguanosine kinase [Source:RGD Symbol;Acc:1304799] |
| Ensembl ID | ENSRNOG00000011617 |
| Bio databases IDs | |
| Aliases | deoxyguanosine kinase |
| Synonyms | deoxyguanosine kinase, dGK, MTDPS3, NCPH, NCPH1, PEOB4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dguok often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- NK
- deoxynucleoside kinase
- protein binding
- deoxyguanosine kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mitochondrial DNA depletion syndrome 3
- lung adenocarcinoma
- lung adenocarcinoma formation
- hereditary disorder
- autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions type 4
- lung squamous cell carcinoma
- squamous cell lung cancer
- noncirrhotic portal hypertension type 1
- mitochondrial DNA depletion syndrome
- early onset hypertension
regulated by
- beta-estradiol
- hippocampal neurons
- EIF4E
role in cell
- proliferation
- abnormal morphology
- development
- depletion in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dguok gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- guanosine metabolic process
- negative regulation of neuron projection development
- purine deoxyribonucleoside metabolic process
- mitochondrial ATP synthesis coupled electron transport
- dGTP metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrial matrix
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- deoxyguanosine kinase activity
- deoxyadenosine kinase activity