Masp1 Gene Summary [Rat]
Enables several functions, including calcium-dependent protein binding activity; protein homodimerization activity; and serine-type endopeptidase activity. Predicted to be involved in complement activation, lectin pathway and negative regulation of complement activation. Located in extracellular space. Human ortholog(s) of this gene implicated in 3MC syndrome 1. Orthologous to human MASP1 (MBL associated serine protease 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Masp1 |
| Official Name | mannan-binding lectin serine peptidase 1 [Source:RGD Symbol;Acc:620213] |
| Ensembl ID | ENSRNOG00000001827 |
| Bio databases IDs | |
| Aliases | mannan-binding lectin serine peptidase 1 |
| Synonyms | 3MC1, CCPII, CRARF, CRARF1, LOC100910195, Mannan-binding lectin serine peptidase 1, MASP, MASP1/3, MASP3, MBL associated serine protease 1, PRSS5, RaRF |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Masp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- Trypsin-like serine protease
- Tryp_SPc
- CUB-EGF module pair
- peptidase
- serine protease domain
- calcium ion binding
- protein binding
- identical protein binding
- EGF-like domain
- EGF_CA
- CCP
- trypsin
- serine endopeptidase
- CUB
- protein homodimerization
- Sushi repeat (SCR repeat)
- Coagulation Factor Xa inhibitory site
- SUSHI repeat
Pathways
Biological processes and signaling networks where the Masp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- hereditary disorder
- 3MC syndrome type 1
- colorectal neoplasm
- colorectal neoplasia
- non-insulin-dependent diabetes mellitus
- sporadic amyotrophic lateral sclerosis
- collagen antibody-induced arthritis
role in cell
- proliferation
- infiltration by
- crizotinib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cytosol
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Masp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- zymogen activation
- complement activation, lectin pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytosol
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- calcium ion binding
- calcium-dependent protein binding
- serine-type endopeptidase activity
- peptidase activity