Stx12 Gene Summary [Rat]
Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in endocytic recycling; regulation of postsynaptic membrane neurotransmitter receptor levels; and synaptic vesicle to endosome fusion. Located in recycling endosome. Is active in glutamatergic synapse; postsynaptic recycling endosome membrane; and synaptic vesicle membrane. Orthologous to human STX12 (syntaxin 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stx12 |
| Official Name | syntaxin 12 [Source:RGD Symbol;Acc:620977] |
| Ensembl ID | ENSRNOG00000011804 |
| Bio databases IDs | |
| Aliases | syntaxin 12 |
| Synonyms | STX13, STX14, Syn13, syntaxin 12, Syntaxin 13 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stx12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SynN
- cytoplasmic domain
- SNARE domain
- Syntaxin-like protein
- Helical region found in SNAREs
- protein binding
- cytosolic tail domain
- SNARE motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
role in cell
- number
- assembly
- fusion
- fusion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- raft fractions
- detergent-soluble membrane fractions
- membrane fraction
- synaptic vesicle membrane
- glutaminergic synapse
- intracellular membrane-bounded organelle
- intracellular compartment
- intracellular space
- perinuclear region
- cellular membrane
- Plasma Membrane
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- trans Golgi network
- endosomal membrane
- nucleoplasm
- synaptic vesicles
- recycling endosomes
- early endosomes
- perinuclear vesicles
- melanosomes
- membrane rafts
- perikaryon
- clathrin-coated vesicles
- phagosomes
- perinuclear recycling endosome
- medial Golgi cisternae
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stx12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- vesicle fusion
- vesicle docking
- cholesterol efflux
- intracellular protein transport
- protein stabilization
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- BLOC-1 complex
- pre-autophagosomal structure
- synaptic vesicle
- phagocytic vesicle
- Golgi apparatus
- Golgi membrane
- nucleoplasm
- early endosome membrane
- intracellular membrane-bounded organelle
- membrane raft
- SNARE complex
- endomembrane system
- vesicle
- recycling endosome
- synaptic vesicle membrane
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- SNAP receptor activity
- SNARE binding