Ints12 Gene Summary [Rat]

Predicted to enable zinc ion binding activity. Predicted to be involved in snRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Orthologous to human INTS12 (integrator complex subunit 12). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Ints12
Official Name
integrator complex subunit 12 [Source:RGD Symbol;Acc:1359136]
Ensembl ID
ENSRNOG00000011844
Bio databases IDs NCBI: 295448 Ensembl: ENSRNOG00000011844
Aliases integrator complex subunit 12
Synonyms 1110020M19Rik, 2810027J24Rik, 4930529N21Rik, A230056J18Rik, INT12, integrator complex subunit 12, PHF22, SBBI22
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ints12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • PHD zinc finger
  • PHD finger superfamily
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • psoriasis
  • chronic obstructive pulmonary disease
regulated by
regulates
  • PRKN

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Ints12 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • snRNA processing
  • regulation of transcription elongation from RNA polymerase II promoter
  • snRNA 3'-end processing

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • nucleoplasm
  • integrator complex

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • metal ion binding

Gene-Specific Assays for Results You Can Trust

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