INTS12 Gene Summary [Human]
INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | INTS12 |
| Official Name | integrator complex subunit 12 [Source:HGNC Symbol;Acc:HGNC:25067] |
| Ensembl ID | ENSG00000138785 |
| Bio databases IDs | |
| Aliases | integrator complex subunit 12, hypothetical nuclear factor SBBI22 |
| Synonyms | 1110020M19Rik, 2810027J24Rik, 4930529N21Rik, A230056J18Rik, INT12, integrator complex subunit 12, PHF22, SBBI22 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human INTS12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- PHD finger superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INTS12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- snRNA processing
- regulation of transcription elongation from RNA polymerase II promoter
- snRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
- integrator complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding