Atp6v1b2 Gene Summary [Rat]
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in synaptic vesicle lumen acidification and vacuolar acidification. Part of vacuolar proton-transporting V-type ATPase, V1 domain. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in autosomal dominant congenital deafness with onychodystrophy. Orthologous to human ATP6V1B2 (ATPase H+ transporting V1 subunit B2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp6v1b2 |
| Official Name | ATPase H+ transporting V1 subunit B2 [Source:RGD Symbol;Acc:620284] |
| Ensembl ID | ENSRNOG00000011891 |
| Bio databases IDs | |
| Aliases | ATPase H+ transporting V1 subunit B2 |
| Synonyms | ATP6B1B2, ATP6B2, Atpase H+ Transporting Lysosomal Isoform 2, ATPase, H+ transporting, lysosomal V1 subunit B2, ATPase H+ transporting V1 subunit B2, DOOD, HO57, LOC105379313, Vacuolar H+ATPase B2, VATB, V-ATPASE B2, V-ATPase V1-B2, Vma2, VPP3, ZLS2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp6v1b2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen ion transporter
- ATP synthase archaeal, B subunit
- ATP-synt_F1_V1_A1_AB_FliI_N
- ATP-synt_F1_V1_A1_AB_FliI_C
- ATP synthase, F1 beta subunit
- ATP synthase alpha/beta family, nucleotide-binding domain
- hydrogen-transporting ATPase activity, rotational mechanism
- protein binding
- ATP synthase alpha/beta family, beta-barrel domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
- V-type (H+)-ATPase V1, B subunit
Pathways
Biological processes and signaling networks where the Atp6v1b2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- non-Hodgkin lymphoma
- neoplasia
- schizophrenia
- Zimmermann-Laband syndrome type 1
- Huntington disease
- autosomal dominant congenital deafness with onychodystrophy
- Zimmermann-Laband syndrome type 2
- hypercalcemia
- chordoma
role in cell
- formation in
- morphology
- formation
- survival
- Clathrin mediated endocytosis by
- replication in
- homeostasis in
- acidification in
- acidification
- viral entry
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- intracellular membrane-bounded organelle
- ruffle
- cellular membrane
- Plasma Membrane
- endosomes
- Endoplasmic Reticulum
- cytosol
- apical membrane
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp6v1b2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ATP metabolic process
- regulation of macroautophagy
- vacuolar acidification
Cellular Component
Where in the cell the gene product is active
- vacuolar proton-transporting V-type ATPase, V1 domain
- extracellular vesicular exosome
- melanosome
- microvillus
- intracellular membrane-bounded organelle
- ruffle
- cytosol
- plasma membrane
- apical plasma membrane
- lysosomal membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- hydrogen ion transmembrane transporter activity
- proton-transporting ATPase activity, rotational mechanism