Otulin Gene Summary [Rat]
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including negative regulation of NF-kappaB transcription factor activity; regulation of defense response; and regulation of signal transduction. Predicted to be part of LUBAC complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in immunodeficiency 107 and otulipenia. Orthologous to human OTULIN (OTU deubiquitinase with linear linkage specificity). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Otulin |
| Official Name | OTU deubiquitinase with linear linkage specificity [Source:RGD Symbol;Acc:2324500] |
| Ensembl ID | ENSRNOG00000012017 |
| Bio databases IDs | |
| Aliases | OTU deubiquitinase with linear linkage specificity |
| Synonyms | AIPDS, AIPDSA, FAM105B, GUM, IMD107, LOC285695, m3Sapc, m7-1Sapc, OTU deubiquitinase with linear linkage specificity |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Otulin often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine-type peptidase
- Peptidase C65 Otubain
- peptidase
- ubiquitin-specific protease
- Peptidase family C101
- protein binding
- OTU-like cysteine protease
- OTU (ovarian tumor) domain family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- autoinflammation, panniculitis, and dermatosis syndrome
- allergic rhinitis
- immunodeficiency 107 with susceptibility to invasive Staphylococcus aureus infection
- dermatitis
role in cell
- signaling in
- Met1 linked ubiquitination in
- ubiquitination in
- interaction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Otulin gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleotide-binding oligomerization domain containing 2 signaling pathway
- negative regulation of NF-kappaB transcription factor activity
- innate immune response
- negative regulation of inflammatory response
- regulation of canonical Wnt receptor signaling pathway
- regulation of tumor necrosis factor-mediated signaling pathway
- proteolysis
- sprouting angiogenesis
- Wnt receptor signaling pathway
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- LUBAC complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- cysteine-type peptidase activity