Id1 Gene Summary [Rat]
Enables identical protein binding activity and proteasome binding activity. Involved in several processes, including cell-abiotic substrate adhesion; negative regulation of cell differentiation; and regulation of gene expression. Located in centrosome. Used to study pulmonary hypertension. Biomarker of cholestasis. Orthologous to human ID1 (inhibitor of DNA binding 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Id1 |
| Official Name | inhibitor of DNA binding 1, HLH protein [Source:RGD Symbol;Acc:2858] |
| Ensembl ID | ENSRNOG00000021750 |
| Bio databases IDs | |
| Aliases | inhibitor of DNA binding 1, HLH protein |
| Synonyms | bHLHb24, D2Wsu140e, ID, ID125A, Id1b, Idb1, inhibitor of DNA binding 1, inhibitor of DNA binding 1, HLH protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Id1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- binding protein
- nuclear localization sequence
- basic Helix Loop Helix (bHLH) domain superfamily
- helix loop helix domain
- helix-loop-helix domain
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Id1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostatic adenocarcinoma
- leukemia
- diabetes mellitus
- neoplasia
- epithelial cancer
- cancer
- adenoma formation
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
role in cell
- phosphorylation in
- apoptosis
- expression in
- proliferation
- growth
- cell viability
- cell death
- formation
- invasion
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- centrosome
- nucleoplasm
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Id1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- circadian regulation of gene expression
- negative regulation of transcription, DNA-dependent
- angiogenesis
- cell differentiation
- transforming growth factor beta receptor signaling pathway
- blood vessel morphogenesis
- negative regulation of transcription by transcription factor localization
- negative regulation of sequence-specific DNA binding transcription factor activity
- blood vessel endothelial cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein dimerization activity