Bco1 Gene Summary [Rat]
Enables beta-carotene 15,15'-dioxygenase activity. Involved in retinoid metabolic process. Predicted to be located in cytosol. Orthologous to human BCO1 (beta-carotene oxygenase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bco1 |
| Official Name | beta-carotene oxygenase 1 [Source:RGD Symbol;Acc:70981] |
| Ensembl ID | ENSRNOG00000012027 |
| Bio databases IDs | |
| Aliases | beta-carotene oxygenase 1 |
| Synonyms | BCDO, BCDO1, BCMO, BCMO1, BCO, beta-carotene oxygenase 1, beta-CD, betaCMOOX, CMO1, Cmoi, β-carotene oxygenase 1, β-CD, β Cmoox, β,β carotene 15,15' dioxygenase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bco1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PLN02258
- beta-carotene 15,15'-monooxygenase
- Retinal pigment epithelial membrane protein
- enzyme
Pathways
Biological processes and signaling networks where the Bco1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- weight gain
- hepatic steatosis
- sialadenitis
- autosomal dominant hypercarotenemia and vitamin A deficiency
- congenital malformation
regulated by
- vitamin A
- heavy metal
- tretinoin
- ISX
- beta-apo-8'-carotenal
- beta-naphthoflavone
- pentobarbital
- Ro41-5253
- beta-apo-12'-carotenal
- fenretinide
role in cell
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bco1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retinoid metabolic process
- retinol metabolic process
- carotene catabolic process
- retinal metabolic process
- vitamin A biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- beta-carotene 15,15'-monooxygenase activity
- metal ion binding
- carotenoid dioxygenase activity