Ncaph Gene Summary [Rat]
Predicted to enable chromatin binding activity. Predicted to be involved in nuclear chromosome segregation; positive regulation of chromosome condensation; and regulation of chromosome segregation. Predicted to act upstream of or within meiotic chromosome condensation and meiotic chromosome segregation. Predicted to be located in condensed nuclear chromosome; cytosol; and nucleoplasm. Predicted to be part of condensin complex. Predicted to be active in chromosome and nucleus. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 23. Orthologous to human NCAPH (non-SMC condensin I complex subunit H). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ncaph |
| Official Name | non-SMC condensin I complex, subunit H [Source:RGD Symbol;Acc:1596799] |
| Ensembl ID | ENSRNOG00000012051 |
| Bio databases IDs | |
| Aliases | non-SMC condensin I complex, subunit H |
| Synonyms | A730011O11Rik, BRRN1, CAP-H, HCAP-H, LOC680089, LOC688088, mCAP-H, MCPH23, NCAPH1, non-SMC condensin I complex subunit H, non-SMC condensin I complex, subunit H |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ncaph often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromatin binding
- protein binding
- Condensin complex subunit 2
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- microcephaly
- autosomal recessive primary microcephaly type 23
- MYC mutation positive B-cell lymphoma
- lymphomagenesis
- B cell cancer
role in cell
- segregation
- condensation
- replicative senescence
- meiosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ncaph gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of chromosome segregation
- meiotic chromosome condensation
- mitotic chromosome condensation
- female meiosis chromosome separation
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- condensin complex
- condensed nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding