NCAPH Gene Summary [Human]
This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | NCAPH |
| Official Name | non-SMC condensin I complex subunit H [Source:HGNC Symbol;Acc:HGNC:1112] |
| Ensembl ID | ENSG00000121152 |
| Bio databases IDs | |
| Aliases | non-SMC condensin I complex subunit H |
| Synonyms | A730011O11Rik, BRRN1, CAP-H, HCAP-H, LOC680089, LOC688088, mCAP-H, MCPH23, NCAPH1, non-SMC condensin I complex subunit H, non-SMC condensin I complex, subunit H |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NCAPH often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromatin binding
- protein binding
- Condensin complex subunit 2
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- microcephaly
- autosomal recessive primary microcephaly type 23
- MYC mutation positive B-cell lymphoma
- lymphomagenesis
- B cell cancer
role in cell
- segregation
- condensation
- replicative senescence
- meiosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NCAPH gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of chromosome segregation
- meiotic chromosome condensation
- mitotic chromosome condensation
- female meiosis chromosome separation
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- condensin complex
- condensed nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding