Asah2 Gene Summary [Rat]
Enables N-acylsphingosine amidohydrolase activity. Involved in ceramide biosynthetic process; ceramide catabolic process; and sphingosine biosynthetic process. Located in several cellular components, including extracellular space; membrane raft; and mitochondrion. Orthologous to several human genes including ASAH2 (N-acylsphingosine amidohydrolase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Asah2 |
| Official Name | N-acylsphingosine amidohydrolase 2 [Source:RGD Symbol;Acc:69410] |
| Ensembl ID | ENSRNOG00000012196 |
| Bio databases IDs | |
| Aliases | N-acylsphingosine amidohydrolase 2 |
| Synonyms | AL/NCDASE, BCDase, CDASE, HNAC1, LCDase, N-acylsphingosine amidohydrolase 2, N-CDase, Neutral ceramidase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Asah2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Neutral/alkaline non-lysosomal ceramidase, N-terminal
- zinc ion binding
- calcium ion binding
- Neutral/alkaline non-lysosomal ceramidase, C-terminal
- enzyme
- protein binding
- ceramidase
Pathways
Biological processes and signaling networks where the Asah2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- diabetes mellitus
- acute kidney injury
- major depression
- cisplatin-induced acute kidney injury
regulates
- JNK
- AKT
- ERK
- lipid
- ceramide
- DDIT3
- D-sphingosine
- C24:1-ceramide
- lactosylceramide
- palmitoyl-coenzyme A
role in cell
- apoptosis
- accumulation in
- loss
- formation
- mitosis
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome fractions
- membrane fraction
- Extracellular Space
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Mitochondria
- caveolae
- mitoplasts
- membrane rafts
- microvilli
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Asah2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid biosynthetic process
- lipid digestion
- sphingosine metabolic process
- apoptotic process
- sphingosine biosynthetic process
- ceramide biosynthetic process
- cellular response to cytokine stimulus
- ceramide metabolic process
- negative regulation of apoptotic signaling pathway
- regulation of mitotic cell cycle
- ceramide catabolic process
Cellular Component
Where in the cell the gene product is active
- caveola
- extracellular vesicular exosome
- mitochondrion
- membrane raft
- Golgi apparatus
- Golgi membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- ceramidase activity
- calcium ion binding