Myh3 Gene Summary [Rat]
Predicted to enable ATP hydrolysis activity; actin filament binding activity; and microfilament motor activity. Predicted to be involved in ATP metabolic process and skeletal muscle contraction. Predicted to be located in contractile muscle fiber. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Human ortholog(s) of this gene implicated in contractures, pterygia, and spondylocarpotarsal fusion syndrome 1A; contractures, pterygia, and spondylocarpotarsal fusion syndrome 1B; distal arthrogryposis type 2A; distal arthrogryposis type 2B; and distal arthrogryposis type 2B3. Orthologous to human MYH3 (myosin heavy chain 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myh3 |
| Official Name | myosin heavy chain 3 [Source:RGD Symbol;Acc:3138] |
| Ensembl ID | ENSRNOG00000046276 |
| Bio databases IDs | |
| Aliases | myosin heavy chain 3 |
| Synonyms | CPSFS1A, CPSFS1B, CPSKF1A, CPSKF1B, DA2A, DA2B, DA2B3, DA8, dMHC, Embryonic Myosin, Embryonic myosin heavy chain, HEMHC, Mhc3, Mhc-emb, MYHC-EMB, Myhs-e, MYHSE1, myosin heavy chain 3, myosin, heavy polypeptide 3, skeletal muscle, embryonic, RNMHCG, SMHCE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Myh3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin phosphatase
- Synaptonemal complex protein 1 (SCP-1)
- microfilament motor protein
- Myosin N-terminal SH3-like domain
- helix-rich Mycoplasma protein
- enzyme
- ATPase
- Laminin Domain I
- chromosome segregation protein SMC, common bacterial type
- Tropomyosin
- HOOK protein coiled-coil region
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Weak chloroplast movement under blue light
- Myosin and Kinesin motor domain
- Hyaluronan mediated motility receptor N-terminal
- rad50
- Myosin tail
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Myosin head (motor domain)
- Alpha helical coiled-coil rod protein (HCR)
- actin filament binding
- RecF/RecN/SMC N terminal domain
- Intermediate filament protein
- Myosin
Pathways
Biological processes and signaling networks where the Myh3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- MYH3-related disorder
- hereditary disorder
- spondylocarpotarsal synostosis syndrome
- autosomal dominant multiple pterygium syndrome
- fibrosis
- contractures, pterygia and variable skeletal fusions syndrome 1B
- distal arthrogryposis
- cryptorchidism
- distal arthrogryposis type 2B3
- freeman-sheldon syndrome
role in cell
- apoptosis
- quantity
- number
- size
- accumulation in
- sliding
- diameter
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- myofibrils
- thin filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Myh3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- embryonic limb morphogenesis
- skeletal muscle contraction
- muscle contraction
- ATP metabolic process
- sarcomere organization
- actin filament-based movement
- face morphogenesis
- muscle filament sliding
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- muscle myosin complex
- cytoplasm
- myosin II complex
- myosin filament
- cytosol
- sarcomere
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATPase activity
- ATP binding
- calmodulin binding
- microfilament motor activity
- myosin phosphatase activity