Myh7 Gene Summary [Rat]
Enables several functions, including ATP binding activity; ATP hydrolysis activity; and identical protein binding activity. Involved in several processes, including cellular response to 3,3',5-triiodo-L-thyronine; cellular response to angiotensin; and cellular response to hydrogen peroxide. Located in myosin filament and sarcomere. Part of muscle myosin complex. Biomarker of congestive heart failure; hypertension; hypothyroidism; and myocardial infarction. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; and hyaline body myopathy (multiple). Orthologous to human MYH7 (myosin heavy chain 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myh7 |
| Official Name | myosin heavy chain 7 [Source:RGD Symbol;Acc:62030] |
| Ensembl ID | ENSRNOG00000016983 |
| Bio databases IDs | |
| Aliases | myosin heavy chain 7 |
| Synonyms | beta cardiac myosin heavy chain, beta-MHC, beta MYHC, beta myosin, Beta Myosin Heavy Chain, beta/SLOW MHC, B-MHC, Bmyo, CMD1S, CMH1, CMYO7A, CMYO7B, CMYP7A, CMYP7B, Fetal beta-myosin heavy chain, Fetal β-myosin heavy chain, foetal beta-myosin heavy chain, foetal β-myosin heavy chain, MHB, Mhc, MHCs, MHC slow, MPD1, Mych slow, MYH-beta/slow, Myhc7, MYHCB, myHC-beta, MyHC-I, myHC-slow, myHC-β, MYH-β/slow, Myosin heavy chain, myosin heavy chain 7, myosin, heavy polypeptide 7, cardiac muscle, beta, myosin, heavy polypeptide 7, cardiac muscle, β, Slow myosin, SPMD, SPMM, SPPM, β cardiac myosin heavy chain, β-MHC, β MYHC, β myosin, β Myosin Heavy Chain, β/SLOW MHC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Myh7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- regulatory domain
- SS1 region
- ATP-binding domain
- Synaptonemal complex protein 1 (SCP-1)
- ATP binding
- microfilament motor protein
- Myosin N-terminal SH3-like domain
- helix-rich Mycoplasma protein
- enzyme
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- ATPase
- chromosome segregation protein SMC, common bacterial type
- Tropomyosin
- IQ domain
- tail domain
- Mitotic checkpoint protein
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Weak chloroplast movement under blue light
- Myosin and Kinesin motor domain
- Yuri gagarin
- Hyaluronan mediated motility receptor N-terminal
- rad50
- S2 domain
- Myosin tail
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Myosin head (motor domain)
- Alpha helical coiled-coil rod protein (HCR)
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- binding protein
- Growth-arrest specific micro-tubule binding
- Coiled-coil domain-containing protein 158
- Intermediate filament protein
- Septation ring formation regulator, EzrA
- Myosin
Pathways
Biological processes and signaling networks where the Myh7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agranulocyte Adhesion and Diapedesis
- Calcium Signaling
- Cardiomyocyte Differentiation via BMP Receptors
- Cellular Effects of Sildenafil (Viagra)
- Factors Promoting Cardiogenesis in Vertebrates
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- ILK Signaling
- Phagosome Formation
- RhoGDI Signaling
- Tight Junction Signaling
- TR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- hypertrophic cardiomyopathy
- hereditary disorder
- familial hypertrophic cardiomyopathy type 1
- cardiomyopathy
- Laing-type distal myopathy
- familial hypertrophic cardiomyopathy
- cardiovascular disorder
- primary dilated cardiomyopathy
- dilated cardiomyopathy 1S
role in cell
- proliferation
- quantity
- morphology
- differentiation
- sliding
- contractility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- myofilaments
- sarcomere
- Golgi membrane
- myofibrils
- A bands
- Z line
- myosin filaments
- thin filaments
- actin stress fibers
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Myh7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transition between fast and slow fiber
- ventricular cardiac muscle tissue morphogenesis
- sarcomere organization
- cardiac muscle contraction
- striated muscle contraction
- adult heart development
- regulation of the force of heart contraction
- regulation of heart rate
- regulation of slow-twitch skeletal muscle fiber contraction
- skeletal muscle contraction
- muscle contraction
- regulation of the force of skeletal muscle contraction
- ATP metabolic process
- cardiac muscle hypertrophy in response to stress
- muscle filament sliding
Cellular Component
Where in the cell the gene product is active
- Z disc
- myosin complex
- muscle myosin complex
- cytoplasm
- myosin II complex
- stress fiber
- myosin filament
- sarcomere
- myofibril
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- calmodulin binding
- protein binding
- microfilament motor activity