ASAH2 Gene Summary [Human]
Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | ASAH2 |
| Official Name | N-acylsphingosine amidohydrolase 2 [Source:HGNC Symbol;Acc:HGNC:18860] |
| Ensembl ID | ENSG00000188611 |
| Bio databases IDs | |
| Aliases | N-acylsphingosine amidohydrolase 2, neutral ceramidase, non-lysosomal ceramidase |
| Synonyms | AL/NCDASE, BCDase, CDASE, HNAC1, LCDase, N-acylsphingosine amidohydrolase 2, N-CDase, Neutral ceramidase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ASAH2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Neutral/alkaline non-lysosomal ceramidase, N-terminal
- zinc ion binding
- calcium ion binding
- Neutral/alkaline non-lysosomal ceramidase, C-terminal
- enzyme
- protein binding
- ceramidase
Pathways
Biological processes and signaling networks where the ASAH2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- diabetes mellitus
- acute kidney injury
- major depression
- cisplatin-induced acute kidney injury
role in cell
- apoptosis
- accumulation in
- loss
- formation
- mitosis
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome fractions
- membrane fraction
- Extracellular Space
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Mitochondria
- caveolae
- mitoplasts
- membrane rafts
- microvilli
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ASAH2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid biosynthetic process
- lipid digestion
- sphingosine metabolic process
- apoptotic process
- sphingosine biosynthetic process
- ceramide biosynthetic process
- cellular response to cytokine stimulus
- ceramide metabolic process
- negative regulation of apoptotic signaling pathway
- regulation of mitotic cell cycle
- ceramide catabolic process
Cellular Component
Where in the cell the gene product is active
- caveola
- extracellular vesicular exosome
- mitochondrion
- membrane raft
- Golgi apparatus
- Golgi membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- ceramidase activity
- calcium ion binding