Mybpc3 Gene Summary [Rat]
Predicted to enable identical protein binding activity and myosin heavy chain binding activity. Predicted to be a structural constituent of muscle. Involved in cardiac muscle contraction and regulation of striated muscle contraction. Located in striated muscle myosin thick filament. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1MM; familial hypertrophic cardiomyopathy; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 4. Orthologous to human MYBPC3 (myosin binding protein C3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mybpc3 |
| Official Name | myosin binding protein C, cardiac [Source:RGD Symbol;Acc:1305950] |
| Ensembl ID | ENSRNOG00000012307 |
| Bio databases IDs | |
| Aliases | myosin binding protein C, cardiac |
| Synonyms | CARDIAC C, CMD1MM, CMH4, cMyBP-C, FHC, LVNC10, MYBP-C, MyBP-C cardiac, myosin binding protein C3, myosin binding protein C, cardiac |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mybpc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tri-helix bundle domain
- ATPase stimulator
- regulatory domain
- C1C2 domain
- globular domain
- immunoglobulin domain
- cardiac MyBP-C motif
- Ig-like C2 domain
- Immunoglobulin I-set domain
- Fibronectin type 3 domain
- protein binding
- identical protein binding
- myosin binding
- structural constituent of muscle
- structural constituent of cytoskeleton
- FN3
- Ig-like C0 domain
- Immunoglobulin like
- M-domain
- immunoglobulin-like protein domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- multiple sclerosis
- hypertrophic cardiomyopathy
- schizophrenia
- familial hypertrophic cardiomyopathy-4
- MYBPC3-related disorder
- cardiomyopathy
- familial hypertrophic cardiomyopathy
- cardiac hypertrophy
- heart failure
role in cell
- proliferation
- activity
- quantity
- morphology
- formation
- contraction
- cell cycle progression
- assembly
- co-localization
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- myofilaments
- sarcomere
- cytosol
- C zone
- myofibrils
- A bands
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mybpc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart morphogenesis
- positive regulation of ATPase activity
- ventricular cardiac muscle tissue morphogenesis
- sarcomere organization
- regulation of muscle filament sliding
- cell adhesion
- cardiac muscle contraction
- regulation of striated muscle contraction
Cellular Component
Where in the cell the gene product is active
- C zone
- cytosol
- A band
- M band
- sarcomere
- striated muscle myosin thick filament
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- structural constituent of muscle
- actin binding
- metal ion binding
- myosin binding
- myosin heavy chain binding
- titin binding
- ATPase activator activity