Pde4dip Gene Summary [Rat]
Enables enzyme binding activity. Involved in protein-containing complex assembly. Located in centrosome and myofibril. Orthologous to human PDE4DIP (phosphodiesterase 4D interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pde4dip |
| Official Name | phosphodiesterase 4D interacting protein [Source:RGD Symbol;Acc:708410] |
| Ensembl ID | ENSRNOG00000018220 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 4D interacting protein |
| Synonyms | 9430063L05RIK, CMYA2, D130016K21RIK, LOC100134230, LOC101060344, LOC64183, MMGL, Myomegalin, phosphodiesterase 4D interacting protein, USMG4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pde4dip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Olduvai domain
- Mitotic checkpoint protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Centrosomin N-terminal motif 1
- rad50
- Synaptonemal complex protein 1 (SCP-1)
- enzyme binding
- Myosin tail
- helix-rich Mycoplasma protein
- Zinc-finger associated domain (zf-AD)
- enzyme
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- Growth-arrest specific micro-tubule binding
- Short myomegalin-like EB1 binding proteins, N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- colorectal cancer
- organismal death
- peripheral arterial disease
- mastocytosis
- idiopathic scoliosis
- Rett syndrome
- epileptic seizure
- cutaneous mastocytosis
role in cell
- phosphorylation in
- binding in
- growth
- migration
- proliferation
- degradation in
- cohesion
- acetylation
- cohesion in
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear Golgi regions
- Nucleus
- centrosome
- Golgi Apparatus
- microtubules
- cis Golgi networks
- myofibrils
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pde4dip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome cycle
- macromolecular complex assembly
- positive regulation of microtubule nucleation
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- Golgi apparatus
- myofibril
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme binding
- binding, bridging