Mesd Gene Summary [Rat]
Predicted to enable low-density lipoprotein particle receptor binding activity. Involved in ossification and protein folding. Located in endoplasmic reticulum. Implicated in osteogenesis imperfecta type 20. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | Mesd |
| Official Name | mesoderm development LRP chaperone [Source:RGD Symbol;Acc:1310344] |
| Ensembl ID | ENSRNOG00000012366 |
| Bio databases IDs | |
| Aliases | mesoderm development LRP chaperone |
| Synonyms | 2210015O11Rik, BOCA, LOC102723954, MESDC2, mesoderm development LRP chaperone, mKIAA0081, msd, OI20 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mesd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chaperone for wingless signalling and trafficking of LDL receptor
- protein binding
- low-density lipoprotein receptor binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteogenesis imperfecta type XX
- gastrulation failure
- idiopathic pulmonary fibrosis
- pulmonary hypertension
role in cell
- signaling in
- phagocytosis by
- ossification by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mesd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization at cell surface
- ossification
- mesoderm development
- phagocytosis
- Wnt receptor signaling pathway
- protein folding
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- low-density lipoprotein particle receptor binding
- protein binding