Shisa2 Gene Summary [Rat]
Predicted to be involved in negative regulation of Wnt signaling pathway and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human SHISA2 (shisa family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Shisa2 |
| Official Name | shisa family member 2 [Source:RGD Symbol;Acc:1561256] |
| Ensembl ID | ENSRNOG00000012521 |
| Bio databases IDs | |
| Aliases | shisa family member 2 |
| Synonyms | 9430059P22Rik, bA398O19.2, C13orf13, hShisa, LOC387914, MAd2, Mem46, mShisa, PRO28631, RGD1561256, shisa, shisa family member 2, TMEM46, WGAR9166 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Shisa2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt and FGF inhibitory regulator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Shisa2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fibroblast growth factor receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding