Fzd3

Predicted to enable PDZ domain binding activity; Wnt receptor activity; and Wnt-protein binding activity. Involved in response to electrical stimulus and response to xenobiotic stimulus. Predicted to be located in several cellular components, including apical plasma membrane; filopodium tip; and lateral plasma membrane. Predicted to be active in glutamatergic synapse and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and schizophrenia. Orthologous to human FZD3 (frizzled class receptor 3). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fzd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Fzd3 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Fzd3 gene, providing context for its role in the cell.