Hs2st1 Gene Summary [Rat]
Predicted to enable heparan sulfate 2-sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process. Predicted to act upstream of or within gene expression; heparin proteoglycan metabolic process; and ureteric bud formation. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human HS2ST1 (heparan sulfate 2-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hs2st1 |
| Official Name | heparan sulfate 2-O-sulfotransferase 1 [Source:RGD Symbol;Acc:1305366] |
| Ensembl ID | ENSRNOG00000012549 |
| Bio databases IDs | |
| Aliases | heparan sulfate 2-O-sulfotransferase 1 |
| Synonyms | 2OST, dJ604K5.2, heparan sulfate 2-O-sulfotransferase 1, heparan sulphate 2-O-sulphotransferase 1, Hs2st, KIAA0448, mKIAA0448, NFSRA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hs2st1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfotransferase
- heparin-sulfate 2-sulfotransferase
- enzyme
- protein binding
- Sulfotransferase family
Pathways
Biological processes and signaling networks where the Hs2st1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurofacioskeletal syndrome with renal agenesis
- neurofacioskeletal syndrome without renal agenesis
- neurofacioskeletal syndrome with or without renal agenesis
- lung squamous cell carcinoma
- squamous cell lung cancer
- osteoporosis
role in cell
- binding
- phosphorylation in
- binding in
- accumulation
- depletion
- ricin resistance
- signaling in
- responsiveness
- guidance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hs2st1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heparan sulfate proteoglycan biosynthetic process, enzymatic modification
- heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
- gene expression
- heparin metabolic process
- ureteric bud formation
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- heparan sulfate 2-O-sulfotransferase activity