Cln8 Gene Summary [Rat]
Predicted to enable ceramide binding activity. Predicted to be involved in several processes, including ceramide metabolic process; cholesterol metabolic process; and lipid homeostasis. Predicted to act upstream of or within several processes, including adult walking behavior; glutamate reuptake; and neurofilament cytoskeleton organization. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 8 and neuronal ceroid lipofuscinosis 8 northern epilepsy variant. Orthologous to human CLN8 (CLN8 transmembrane ER and ERGIC protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cln8 |
| Official Name | CLN8, transmembrane ER and ERGIC protein [Source:RGD Symbol;Acc:1359518] |
| Ensembl ID | ENSRNOG00000012565 |
| Bio databases IDs | |
| Aliases | CLN8, transmembrane ER and ERGIC protein |
| Synonyms | C8orf61, CLN8 transmembrane ER and ERGIC protein, CLN8, transmembrane ER and ERGIC protein, EPMR, LOC101927714, mnd, TLCD6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cln8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TLC domain
- sphingolipid binding
- binding protein
- protein binding
- cytosolic tail domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neuronal ceroid lipofuscinosis
- hereditary disorder
- neuronal ceroid lipofuscinosis 8
- neuronal ceroid lipofuscinosis 8 northern epilepsy variant
role in cell
- binding in
- apoptosis
- differentiation
- size
- organization
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- endoplasmic reticulum membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cln8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retina development in camera-type eye
- regulation of cell size
- cholesterol metabolic process
- nervous system development
- ceramide biosynthetic process
- negative regulation of proteolysis
- associative learning
- phospholipid metabolic process
- negative regulation of neuron apoptotic process
- adult walking behavior
- photoreceptor cell maintenance
- social behavior
- lysosome organization
- neurofilament cytoskeleton organization
- lipid homeostasis
- protein catabolic process
- lipid biosynthetic process
- somatic motor neuron differentiation
- ceramide metabolic process
- visual perception
- mitochondrial membrane organization
- neuromuscular process controlling posture
- lipid transport
- musculoskeletal movement
- glutamate uptake involved in synaptic transmission
- neuromuscular process controlling balance
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- mitochondrion
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- ceramide binding
- protein binding