Ppt1 Gene Summary [Rat]
Predicted to enable lysophosphatidic acid binding activity; sulfatide binding activity; and thiolester hydrolase activity. Predicted to be involved in several processes, including lysosomal lumen acidification; negative regulation of toll-like receptor 9 signaling pathway; and positive regulation of endocytosis. Predicted to act upstream of or within several processes, including endocytosis; grooming behavior; and regulation of phospholipase A2 activity. Located in neuronal cell body and synaptic vesicle. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 1. Orthologous to human PPT1 (palmitoyl-protein thioesterase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppt1 |
| Official Name | palmitoyl-protein thioesterase 1 [Source:RGD Symbol;Acc:61994] |
| Ensembl ID | ENSRNOG00000012616 |
| Bio databases IDs | |
| Aliases | palmitoyl-protein thioesterase 1 |
| Synonyms | 9530043G02RIK, CLN1, D4Ertd184e, INCL, palmitoyl-protein thioesterase 1, PPT |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- lipid binding
- binding protein
- alpha/beta hydrolases
- Palmitoyl protein thioesterase
- enzyme
- protein binding
- palmitoyl-(protein) hydrolase
- phospholipase A2 inhibitor
- acyl-CoA hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- seizures
- neuronal ceroid lipofuscinosis 1
- retinitis pigmentosa
- astrocytosis
- neuronal ceroid lipofuscinosis
- myoclonus
- hereditary disorder
- neurodegeneration
- gliosis
role in cell
- expression in
- apoptosis
- cell death
- activation
- growth
- number
- abnormal morphology
- development
- organization
- pinocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- intracellular membrane-bounded organelle
- Extracellular Space
- cellular membrane
- Nucleus
- lysosome
- Golgi Apparatus
- cytosol
- lysosome membrane
- lysosomal compartment
- synaptic vesicles
- synaptosomes
- membrane rafts
- perikaryon
- axons
- dendrites
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- nervous system development
- protein depalmitoylation
- adult locomotory behavior
- associative learning
- negative regulation of neuron apoptotic process
- grooming behavior
- negative regulation of cell growth
- membrane raft organization
- positive regulation of receptor-mediated endocytosis
- sphingolipid catabolic process
- fatty-acyl-CoA biosynthetic process
- protein catabolic process
- negative regulation of toll-like receptor 9 signaling pathway
- lysosomal lumen acidification
- brain development
- neuron development
- visual perception
- receptor-mediated endocytosis
- neurotransmitter secretion
- positive regulation of pinocytosis
- negative regulation of apoptotic process
- lipid catabolic process
- regulation of synapse structure and activity
- pinocytosis
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- lysosomal lumen
- Golgi apparatus
- neuronal cell body
- extracellular region
- lysosomal membrane
- lysosome
- nucleus
- dendrite
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- membrane raft
- cytosol
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding
- palmitoyl-(protein) hydrolase activity
- lysophosphatidic acid binding
- long-chain acyl-CoA hydrolase activity