Sec24a Gene Summary [Rat]
Predicted to enable SNARE binding activity and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading. Predicted to act upstream of or within cholesterol homeostasis; positive regulation of protein secretion; and regulation of cholesterol transport. Predicted to be located in cytosol and endoplasmic reticulum membrane. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Orthologous to human SEC24A (SEC24 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sec24a |
| Official Name | SEC24 homolog A, COPII coat complex component [Source:RGD Symbol;Acc:1309451] |
| Ensembl ID | ENSRNOG00000004563 |
| Bio databases IDs | |
| Aliases | SEC24 homolog A, COPII coat complex component |
| Synonyms | LOC103689920, SEC24 homolog A, COPII coat complex component |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sec24a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sec23/Sec24 helical domain
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- Sec23/Sec24 trunk domain
- zinc ion binding
- Gelsolin repeat
- vWFA
- Sec23/Sec24 beta-sandwich domain
- protein binding
- Sec23/Sec24 zinc finger
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- Huntington disease
- schizophrenia
- neonatal late-onset sepsis
- chronic obstructive pulmonary disease
- Hutchinson-Gilford progeria syndrome
- allergic rhinitis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
role in cell
- expression in
- proliferation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- vesicles
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum exit sites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sec24a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- regulation of cholesterol transport
- cargo loading into COPII-coated vesicle
- positive regulation of protein secretion
- intracellular protein transport
- cholesterol homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- ER to Golgi transport vesicle membrane
- cytosol
- endoplasmic reticulum exit site
- COPII vesicle coat
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- SNARE binding