Fzd7 Gene Summary [Rat]
Predicted to enable several functions, including PDZ domain binding activity; Wnt receptor activity; and Wnt-protein binding activity. Predicted to be involved in several processes, including Wnt signaling pathway; negative regulation of cell differentiation; and regulation of signal transduction. Predicted to act upstream of or within several processes, including T cell differentiation in thymus; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; and substrate adhesion-dependent cell spreading. Predicted to be located in recycling endosome membrane. Predicted to be active in plasma membrane. Orthologous to human FZD7 (frizzled class receptor 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fzd7 |
| Official Name | frizzled class receptor 7 [Source:RGD Symbol;Acc:2321905] |
| Ensembl ID | ENSRNOG00000016119 |
| Bio databases IDs | |
| Aliases | frizzled class receptor 7 |
| Synonyms | Frizzled 7, frizzled class receptor 7, Fz7, FzE3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fzd7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Wnt-protein binding
- Frizzled/Smoothened family membrane region
- frizzled binding
- Wnt receptor
- Fz domain
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
- PDZ-domain binding
- phosphatidylinositol-4,5-bisphosphate binding
- PDZ binding motif
- cysteine rich domain
Pathways
Biological processes and signaling networks where the Fzd7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Basal Cell Carcinoma Signaling
- Cellular Effects of Sildenafil (Viagra)
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- CREB Signaling in Neurons
- Factors Promoting Cardiogenesis in Vertebrates
- G-Protein Coupled Receptor Signaling
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- Wnt/Ca+ pathway
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- epithelial neoplasia
- benign neoplasia
- androgenic alopecia
- liver cancer
- gastrointestinal neoplasia
- neoplasia
- cerebral hemorrhage
- endometriosis
- brain edema
role in cell
- expression in
- growth
- differentiation
- proliferation
- migration
- cell viability
- development
- sphere formation
- signaling in
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- Endoplasmic Reticulum
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fzd7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mesenchymal to epithelial transition
- positive regulation of phosphorylation
- stem cell maintenance
- G-protein coupled receptor signaling pathway
- T cell differentiation in thymus
- neuron differentiation
- positive regulation of epithelial cell proliferation involved in wound healing
- regulation of transcription, DNA-dependent
- positive regulation of MAPK cascade
- negative regulation of ectodermal cell fate specification
- cellular response to retinoic acid
- somatic stem cell division
- negative regulation of cell-substrate adhesion
- positive regulation of transcription, DNA-dependent
- positive regulation of JNK cascade
- regulation of canonical Wnt receptor signaling pathway
- negative regulation of cardiac muscle cell differentiation
- substrate adhesion-dependent cell spreading
- canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway, planar cell polarity pathway
- satellite cell maintenance involved in skeletal muscle regeneration
- non-canonical Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- membrane
- recycling endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4,5-bisphosphate binding
- G-protein coupled receptor activity
- Wnt-activated receptor activity
- frizzled binding
- protein binding
- PDZ domain binding
- Wnt-protein binding