Akr1d1 Gene Summary [Rat]
Enables 3-oxo-5-beta-steroid 4-dehydrogenase activity. Predicted to be involved in digestion and steroid metabolic process. Predicted to act upstream of or within bile acid biosynthetic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 2. Orthologous to human AKR1D1 (aldo-keto reductase family 1 member D1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akr1d1 |
| Official Name | aldo-keto reductase family 1, member D1 [Source:RGD Symbol;Acc:620752] |
| Ensembl ID | ENSRNOG00000013004 |
| Bio databases IDs | |
| Aliases | aldo-keto reductase family 1, member D1 |
| Synonyms | 3o5bred, 5 beta-reductase, 5 β R, 5 β-reductase, aldo-keto reductase family 1 member D1, aldo-keto reductase family 1, member D1, CBAS2, delta 4-3-KETOSEROID-5-beta-REDUCTASE, Delta(4)-3-oxosteroid 5-beta-reductase, SRD5B1, δ 4-3-KETOSEROID-5-β-REDUCTASE, δ(4)-3-oxosteroid 5-β-reductase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Akr1d1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cortisone beta-reductase
- Aldo-keto reductase (AKR) superfamily
- aldo-keto reductase
- Aldo/keto reductase family
- enzyme
- protein binding
- 3-oxo-5beta-steroid 4-dehydrogenase
- steroid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- congenital bile acid synthesis defect type 2
- liver cancer
- epithelial cancer
- melasma
- acne vulgaris
- congenital bile acid synthesis defect
- hepatitis B virus-related hepatocellular carcinoma
- rosacea
- rheumatoid arthritis
regulates
- cholesterol
- bile acid
- glucocorticoid
- androgen
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Akr1d1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- androgen metabolic process
- cholesterol catabolic process
- digestion
- bile acid catabolic process
- C21-steroid hormone metabolic process
- bile acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- steroid dehydrogenase activity
- ketosteroid monooxygenase activity
- alditol:NADP+ 1-oxidoreductase activity
- delta4-3-oxosteroid 5beta-reductase activity
- aldo-keto reductase (NADP) activity
- steroid binding