Aplnr Gene Summary [Rat]
Enables mechanoreceptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and regulation of body fluid levels. Located in plasma membrane. Orthologous to human APLNR (apelin receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aplnr |
| Official Name | apelin receptor [Source:RGD Symbol;Acc:621645] |
| Ensembl ID | ENSRNOG00000009227 |
| Bio databases IDs | |
| Aliases | apelin receptor |
| Synonyms | AGTRL1, Apelin Receptor, APJ, APJR, Apj receptor, HG11, msr/apj |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aplnr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- peptide binding
- Cholecystokinin A receptor, N-terminal
- signaling receptor activity
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Aplnr gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apelin Adipocyte Signaling Pathway
- Apelin Cardiac Fibroblast Signaling Pathway
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Apelin Liver Signaling Pathway
- Apelin Muscle Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Breast Cancer Regulation by Stathmin1
- cAMP-mediated signaling
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- G-Protein Coupled Receptor Signaling
- Gαi Signaling
- Phagosome Formation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- spontaneous hypertension
- Parkinson disease
- cardiac hypertrophy
- idiopathic dilated cardiomyopathy
- Huntington disease
- organismal death
- nasopharyngeal carcinoma
- nasopharyngeal cancer
regulated by
- APLN
- ERK
- lipopolysaccharide
- Akt
- ADCY
- forskolin
- Immunoglobulin
- insulin
- VEGF
- E339-3D6
role in cell
- proliferation
- migration
- expression in
- function
- differentiation
- phosphorylation in
- activation
- production in
- activation in
- entrance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear membrane fraction
- membrane fraction
- Cytoplasm
- cell surface
- cell periphery
- cellular membrane
- Nucleus
- cytoplasmic vesicles
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aplnr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- atrioventricular valve development
- endocardial cushion formation
- coronary vasculature development
- positive regulation of release of sequestered calcium ion into cytosol
- vasculogenesis
- venous blood vessel development
- ventricular septum morphogenesis
- negative regulation of cAMP-mediated signaling
- positive regulation of angiogenesis
- adult heart development
- gastrulation
- heart development
- negative regulation of gene expression
- blood vessel development
- aorta development
- angiogenesis
- vasculature development
- regulation of gene expression
- heart looping
- regulation of body fluid levels
- vascular smooth muscle cell differentiation
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- signaling receptor activity
- apelin receptor activity