Etnppl Gene Summary [Rat]
Predicted to enable ethanolamine-phosphate phospho-lyase activity. Predicted to act upstream of or within several processes, including cellular response to glucocorticoid stimulus; ceramide phosphoethanolamine catabolic process; and phospholipid transfer to membrane. Predicted to be located in membrane and mitochondrion. Orthologous to human ETNPPL (ethanolamine-phosphate phospho-lyase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Etnppl |
| Official Name | ethanolamine-phosphate phospho-lyase [Source:RGD Symbol;Acc:1590098] |
| Ensembl ID | ENSRNOG00000045743 |
| Bio databases IDs | |
| Aliases | ethanolamine-phosphate phospho-lyase |
| Synonyms | 1300019H02Rik, AGXT2L1, ethanolamine-phosphate phospho-lyase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Etnppl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 4-aminobutyrate aminotransferase, eukaryotic type
- ethanolamine-phosphate phospho-lyase
- Aminotransferase class-III
- succinylornithine transaminase family
- AAT_I
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- Huntington disease
- hepatocellular carcinoma
- diabetic nephropathy
- eosinophilia
- survival
role in cell
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Etnppl gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- transaminase activity
- ethanolamine-phosphate phospho-lyase activity