Ldha Gene Summary [Rat]
Enables several functions, including L-lactate dehydrogenase activity; NAD binding activity; and identical protein binding activity. Involved in several processes, including cellular response to phorbol 13-acetate 12-myristate; response to estrogen; and response to hydrogen peroxide. Predicted to be located in sperm fibrous sheath. Predicted to be part of oxidoreductase complex. Predicted to be active in cytosol and mitochondrion. Biomarker of hyperglycemia and hypertension. Orthologous to human LDHA (lactate dehydrogenase A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ldha |
| Official Name | lactate dehydrogenase A [Source:RGD Symbol;Acc:2996] |
| Ensembl ID | ENSRNOG00000013009 |
| Bio databases IDs | |
| Aliases | lactate dehydrogenase A |
| Synonyms | CDK1, GSD11, HEL-S-133P, I lactate dehydrogenase (m chain), l7R2, lactate dehydrogenase 1 A chain, Lactate dehydrogenase 5, Lactate dehydrogenase a, LACTATE DEHYDROGENASE M4, LDH1, LDH5, LDHM, LDH muscle subunit, LOC100364670, PIG19, Subunit A of lactate dehydrogenase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ldha often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- NAD or NADH binding
- kinase binding
- L-lactate dehydrogenase
- lactate/malate dehydrogenase, NAD binding domain
- enzyme
- lactate/malate dehydrogenase, alpha/beta C-terminal domain
- protein binding
- identical protein binding
- lactate dehydrogenase
- malate dehydrogenase, NAD-dependent
Pathways
Biological processes and signaling networks where the Ldha gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver neoplasia
- cancer
- tumorigenesis
- Parkinson disease
- prostate cancer
- abdominal cancer
- edema
- epithelial cancer
- chromophobe renal cell carcinoma
- chromophobe renal cancer
role in cell
- expression in
- inhibition
- production in
- apoptosis
- formation
- cell death
- phosphorylation in
- quantity
- growth
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell surface
- cellular membrane
- cytosol
- sperm fibrous sheath
- peroxisomes
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ldha gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycolysis
- lactate metabolic process
- pyruvate metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- mitochondrion
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- L-lactate dehydrogenase activity
- protein binding
- cadherin binding