Pcdh8 Gene Summary [Rat]
Predicted to enable calcium ion binding activity. Involved in chemical synaptic transmission; modulation of chemical synaptic transmission; and regulation of synaptic membrane adhesion. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic membrane. Orthologous to human PCDH8 (protocadherin 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcdh8 |
| Official Name | protocadherin 8 [Source:RGD Symbol;Acc:69350] |
| Ensembl ID | ENSRNOG00000013101 |
| Bio databases IDs | |
| Aliases | protocadherin 8 |
| Synonyms | 1700080P15Rik, ARCADLIN, PAPC, protocadherin 8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pcdh8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- Cadherin-like
- Cadherin repeat-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Parkinson disease
- tumorigenesis
- androgenic alopecia
regulates
role in cell
- long-term potentiation
- adhesion
- plasticity
- aggregation
- interaction
- modulation
- excitation
- establishment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- postsynaptic membrane
- synapse
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pcdh8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- somitogenesis
- cell-cell signaling
- regulation of synaptic transmission
- synaptic transmission
- morphogenesis of embryonic epithelium
- cell adhesion
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- dendrite
- postsynaptic membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding