Bdnf Gene Summary [Rat]
Enables neurotrophin TRKB receptor binding activity. Involved in several processes, including behavioral response to cocaine; neuron projection development; and regulation of neuronal synaptic plasticity. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including mitochondrial crista; perikaryon; and secretory vesicle. Used to study several diseases, including alcohol dependence; cocaine dependence; neuropathy (multiple); status epilepticus; and transient cerebral ischemia. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; brain disease (multiple); cognitive disorder (multiple); and neuropathy (multiple). Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; cocaine dependence; cognitive disorder (multiple); congenital central hypoventilation syndrome; and neurodegenerative disease (multiple). Orthologous to human BDNF (brain derived neurotrophic factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bdnf |
| Official Name | brain-derived neurotrophic factor [Source:RGD Symbol;Acc:2202] |
| Ensembl ID | ENSRNOG00000047466 |
| Bio databases IDs | |
| Aliases | brain-derived neurotrophic factor |
| Synonyms | ANON2, Brain derived neurotrophic factor, BULN2, OCD1, tBDNF |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bdnf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- loop domain
- pro domain
- neurotrophin TRKB receptor binding
- growth factor
- Nerve growth factor family
Pathways
Biological processes and signaling networks where the Bdnf gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- CDK5 Signaling
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Human Embryonic Stem Cell Pluripotency
- Huntington's Disease Signaling
- Neuroinflammation Signaling Pathway
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Neurotrophin/TRK Signaling
- PEDF Signaling
- Serotonin Receptor Signaling
- Thyroid Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diarrhea
- plasma cell myeloma
- neoplasia
- weight loss
- liver cancer
- cancer
- epithelial cancer
- neurodegeneration
- obesity
- metabolic syndrome X
regulated by
- cyclosporin A
- midazolam
- tetrachlorodibenzodioxin
- lovastatin
- fingolimod
- Ca2+
- PTEN
- FSH
- dopamine
- D-mannose
role in cell
- growth
- cell viability
- synthesis in
- killing
- activation in
- formation
- formation in
- expression in
- apoptosis
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- en passant terminal
- Cytoplasm
- cell surface
- intracellular space
- somatodendritic region
- perinuclear region
- Nucleus
- vesicles
- Golgi Apparatus
- granules
- endoplasmic reticulum lumen
- mitochondrial inner membrane
- perinuclear space
- alpha granules
- dendritic spine head
- synaptic vesicles
- neurites
- nerve ending
- dendrite initial segments
- synaptosomes
- synapse
- dense-core vesicles
- cytoplasmic vesicles
- secretory vesicles
- secretory granules
- membrane processes
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- mossy fiber boutons
- presynaptic terminals
- axon branches
- clathrin-coated vesicles
- cis Golgi cisternae
- mossy fibers
- apical processes
- vesicle fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bdnf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of receptor binding
- nervous system development
- neuron projection morphogenesis
- transmembrane receptor protein tyrosine kinase signaling pathway
- axon guidance
- collateral sprouting
- negative regulation of neuron apoptotic process
- nerve development
- positive regulation of collateral sprouting
- synapse assembly
- brain-derived neurotrophic factor receptor signaling pathway
- regulation of protein localization at cell surface
- regulation of synaptic transmission
- positive regulation of brain-derived neurotrophic factor receptor signaling pathway
- positive regulation of neuron projection development
- negative regulation of myotube differentiation
- positive regulation of synapse assembly
- negative regulation of apoptotic signaling pathway
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- dendrite
- endoplasmic reticulum lumen
- extracellular space
- perinuclear region of cytoplasm
- cytoplasm
- synaptic vesicle
- extracellular region
- axon
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- nerve growth factor receptor binding