Wwc2 Gene Summary [Rat]
Predicted to enable kinase binding activity and signaling adaptor activity. Predicted to be involved in several processes, including hippo signaling; negative regulation of hippo signaling; and negative regulation of organ growth. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human WWC2 (WW and C2 domain containing 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wwc2 |
| Official Name | WW and C2 domain containing 2 [Source:RGD Symbol;Acc:1559427] |
| Ensembl ID | ENSRNOG00000013248 |
| Bio databases IDs | |
| Aliases | WW and C2 domain containing 2 |
| Synonyms | 5330431C14Rik, BOMB, D8Ertd594e, FLJ22029, RGD1559427, WW and C2 domain containing 2, WW, C2 and coiled-coil domain containing 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wwc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain with 2 conserved Trp (W) residues
- kinase binding
- Hyaluronan mediated motility receptor N-terminal
- WW
- protein binding activity, bridging
- protein binding
- WW domain
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- biliary tract cancer
- cancer
- digestive system cancer
- epithelial neoplasia
- acute myeloid leukemia
- sertoli cell only syndrome
- epithelial cancer
- gout
- liver cancer
- liver neoplasia
regulates
- YAP1
- RNA polymerase II
- DNA promoter
- DNA endogenous promoter
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wwc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of hippo signaling cascade
- negative regulation of hippo signaling cascade
- negative regulation of cell proliferation
- regulation of transcription, DNA-dependent
- hippo signaling cascade
- negative regulation of organ growth
- cell migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- signaling adaptor activity
- kinase binding
- binding, bridging