Mctp1 Gene Summary [Rat]
Predicted to enable calcium ion binding activity. Involved in negative regulation of cell migration; negative regulation of endocytosis; and negative regulation of response to oxidative stress. Located in recycling endosome and synaptic vesicle membrane. Orthologous to human MCTP1 (multiple C2 and transmembrane domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mctp1 |
| Official Name | multiple C2 and transmembrane domain containing 1 [Source:RGD Symbol;Acc:1305199] |
| Ensembl ID | ENSRNOG00000013282 |
| Bio databases IDs | |
| Aliases | multiple C2 and transmembrane domain containing 1 |
| Synonyms | 2810465F10Rik, Mctp1-ps1, multiple C2 and transmembrane domain containing 1, multiple C2 domains, transmembrane 1, RGD1305199 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mctp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium ion binding
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nonalcoholic steatohepatitis
- neoplasia
- cancer
- COVID-19
- metabolic syndrome X
- breast carcinoma
- Huntington disease
- keratoconus
- necrotizing enterocolitis
- multiple sclerosis
role in cell
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- cellular membrane
- endoplasmic reticulum membrane
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mctp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neurotransmitter secretion
- negative regulation of endocytosis
- regulation of neuronal synaptic plasticity
- calcium-mediated signaling
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- recycling endosome
- synaptic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- calcium-dependent phospholipid binding