Nkx2-3 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including hematopoietic or lymphoid organ development; mononuclear cell differentiation; and saliva secretion. Predicted to be active in nucleus. Orthologous to human NKX2-3 (NK2 homeobox 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nkx2-3 |
| Official Name | NK2 homeobox 3 [Source:RGD Symbol;Acc:1308521] |
| Ensembl ID | ENSRNOG00000016656 |
| Bio databases IDs | |
| Aliases | NK2 homeobox 3 |
| Synonyms | CSX3, NK2.3, NK2 homeobox 3, NKX2.3, NKX2C, NKX4-3, tinman |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nkx2-3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- inflammatory bowel disease
- cachexia
- Crohn disease
- ulcerative colitis
- colorectal cancer
role in cell
- quantity
- expression in
- phosphorylation in
- proliferation
- differentiation
- abnormal morphology
- migration
- number
- growth
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nkx2-3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gland morphogenesis
- spleen development
- triglyceride metabolic process
- transcription from RNA polymerase II promoter
- lymph node development
- odontogenesis of dentin-containing tooth
- CD4-positive, alpha-beta T cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- leukocyte homeostasis
- post-embryonic digestive tract morphogenesis
- plasma cell differentiation
- Peyer's patch development
- cell differentiation
- leukocyte migration
- regulation of epithelial cell proliferation
- macrophage differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity