Matr3 Gene Summary [Rat]
Predicted to enable identical protein binding activity and miRNA binding activity. Predicted to be involved in activation of innate immune response and post-transcriptional regulation of gene expression. Predicted to act upstream of or within blastocyst formation; heart valve development; and ventricular septum development. Located in nuclear matrix. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 21. Orthologous to human MATR3 (matrin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Matr3 |
| Official Name | matrin 3 [Source:RGD Symbol;Acc:3052] |
| Ensembl ID | ENSRNOG00000019875 |
| Bio databases IDs | |
| Aliases | matrin 3 |
| Synonyms | 1110061A14RIK, 2810017I02Rik, ALS21, D030046F20Rik, matrin 3, mKIAA0723, MPD2, P130/MAT3, snhg4, VCPDM |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Matr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- U1 zinc finger
- protein binding
- structural molecule
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- amyotrophic lateral sclerosis type 21
role in cell
- expression in
- survival
- degradation in
- retention in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear pores
- inner nuclear membrane
- interchromatin granule clusters
- nuclear matrix
- chromatin
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Matr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- posttranscriptional regulation of gene expression
- activation of innate immune response
- heart valve development
- ventricular septum development
- innate immune response
- blastocyst formation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear inner membrane
- membrane
- nuclear matrix
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- identical protein binding
- zinc ion binding
- RNA binding
- protein binding
- structural molecule activity