Gsta1 Gene Summary [Rat]
Enables dinitrosyl-iron complex binding activity; glutathione binding activity; and glutathione transferase activity. Involved in response to nutrient levels and xenobiotic catabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to human GSTA1 (glutathione S-transferase alpha 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gsta1 |
| Official Name | glutathione S-transferase alpha 1 [Source:RGD Symbol;Acc:2753] |
| Ensembl ID | ENSRNOG00000013484 |
| Bio databases IDs | |
| Aliases | glutathione S-transferase alpha 1 |
| Synonyms | glutathione S-transferase alpha 1, glutathione S-transferase α 1, GST 2-2, Gsta3, Gsta3-3, Gsta5, GST AA, GSTYa1, GST Yc1, LOC108348061, Yc1 |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gsta1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- Glutathione S-transferase, N-terminal domain
- binding protein
- glutathione transferase
- fatty acid binding
- steroid D-isomerase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- glutathione peroxidase
Pathways
Biological processes and signaling networks where the Gsta1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- glutathione
- mechlorethamine
- 4-hydroxynonenal
- 5-androstene-3,17-dione
- 1,2-epoxy-3-(p-nitrophenoxy)propane
- ethacrynic acid
- cumene hydroperoxide
- 1-chloro-2,4-dinitrobenzene
- styrene oxide
- 2-(acetoxyamino)-1-methyl-6-phenylimidazo(4,5-b)pyridine
role in cell
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol