Gdf2 Gene Summary [Rat]
Predicted to enable cytokine activity; growth factor activity; and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; regulation of endothelial cell proliferation; and transforming growth factor beta receptor superfamily signaling pathway. Predicted to act upstream of or within osteoblast differentiation; positive regulation of gene expression; and positive regulation of transcription by RNA polymerase II. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in hereditary hemorrhagic telangiectasia. Orthologous to human GDF2 (growth differentiation factor 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gdf2 |
| Official Name | growth differentiation factor 2 [Source:RGD Symbol;Acc:1586196] |
| Ensembl ID | ENSRNOG00000057751 |
| Bio databases IDs | |
| Aliases | growth differentiation factor 2 |
| Synonyms | BMP-9, growth differentiation factor 2, HHT5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gdf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- TGF_beta_SF
- Transforming growth factor beta like domain
- protein binding
- cytokine
- growth factor
- TGF-beta propeptide
Pathways
Biological processes and signaling networks where the Gdf2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- non-insulin-dependent diabetes mellitus
- pulmonary hypertensive arterial disease
- hepatocellular carcinoma
- liver cancer
- disrupted blood brain barrier
- hypoxia
- hereditary hemorrhagic telangiectasia type 5
role in cell
- downregulation in
- formation
- formation in
- phosphorylation in
- apoptosis
- expression in
- activation in
- differentiation
- growth
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gdf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- positive regulation of cartilage development
- transcription from RNA polymerase II promoter
- blood vessel morphogenesis
- vasculogenesis
- positive regulation of endothelial cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of Notch signaling pathway
- positive regulation of angiogenesis
- cellular iron ion homeostasis
- activin receptor signaling pathway
- angiogenesis
- cellular response to BMP stimulus
- negative regulation of cell growth
- ossification
- patterning of blood vessels
- positive regulation of transcription, DNA-dependent
- BMP signaling pathway
- osteoblast differentiation
- positive regulation of SMAD protein import into nucleus
- negative regulation of endothelial cell migration
- negative regulation of blood vessel endothelial cell migration
- negative regulation of DNA replication
- positive regulation of BMP signaling pathway
- positive regulation of interleukin-8 production
- positive regulation of epithelial cell differentiation
- negative regulation of endothelial cell proliferation
- positive regulation of endothelial cell proliferation
- cartilage development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- protein serine/threonine kinase activator activity
- cytokine activity