Upk3a Gene Summary [Rat]
Predicted to be involved in epithelial cell differentiation; urea transport; and water transport. Predicted to act upstream of or within several processes, including potassium ion homeostasis; sodium ion homeostasis; and urinary bladder development. Predicted to be located in apical plasma membrane. Predicted to be active in apical plasma membrane urothelial plaque. Orthologous to human UPK3A (uroplakin 3A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Upk3a |
| Official Name | uroplakin 3A [Source:RGD Symbol;Acc:1310633] |
| Ensembl ID | ENSRNOG00000013593 |
| Bio databases IDs | |
| Aliases | uroplakin 3A |
| Synonyms | 1110017C07Rik, UP3A, UPIII, UPIIIA, UPK3, uroplakin 3A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Upk3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Uroplakin IIIb, IIIa and II
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- discoidal-fusiform vesicle
- cellular membrane
- Plasma Membrane
- apical cell surfaces
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Upk3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- urea transport
- water transport
- urinary bladder development
- potassium ion homeostasis
- kidney development
- cell morphogenesis
- sodium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding