Upk3a Gene Summary [Mouse]
Acts upstream of or within several processes, including potassium ion homeostasis; urea transport; and urinary bladder development. Located in apical plasma membrane. Is active in apical plasma membrane urothelial plaque. Is expressed in several structures, including alimentary system; genitourinary system; lung; notochord; and olfactory epithelium. Used to study vesicoureteral reflux. Orthologous to human UPK3A (uroplakin 3A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Upk3a |
| Official Name | uroplakin 3A [Source:MGI Symbol;Acc:MGI:98914] |
| Ensembl ID | ENSMUSG00000022435 |
| Bio databases IDs | |
| Aliases | uroplakin 3A |
| Synonyms | 1110017C07Rik, UP3A, UPIII, UPIIIA, UPK3, uroplakin 3A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Upk3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Uroplakin IIIb, IIIa and II
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- discoidal-fusiform vesicle
- cellular membrane
- Plasma Membrane
- apical cell surfaces
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Upk3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- urea transport
- water transport
- urinary bladder development
- potassium ion homeostasis
- kidney development
- cell morphogenesis
- sodium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding