Ntng2 Gene Summary [Rat]
Predicted to be involved in several processes, including regulation of cell projection organization; regulation of presynapse assembly; and synapse organization. Predicted to be located in axon and plasma membrane. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic active zone membrane. Orthologous to human NTNG2 (netrin G2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ntng2 |
| Official Name | netrin G2 [Source:RGD Symbol;Acc:1307089] |
| Ensembl ID | ENSRNOG00000013694 |
| Bio databases IDs | |
| Aliases | netrin G2 |
| Synonyms | 2610016D08RIK, bA479K20.1, Laminet2, LHLL9381, Lmnt2, NEDBASH, NetrinG2, NTNG1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ntng2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Laminin-type epidermal growth factor-like domai
- Laminin N-terminal (Domain VI)
- protein binding
- EGF_CA
- Laminin EGF domain
Pathways
Biological processes and signaling networks where the Ntng2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder with behavioral abnormalities, absent speech and hypotonia
- androgenic alopecia
- Crohn disease
- neurodevelopmental disorder
- schizophrenia
- COVID-19
- systemic lupus erythematosus
- carcinoma in situ
- epithelial cancer in situ
- Bell palsy
regulates
role in cell
- adhesion
- assembly
- development
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cell surface
- Extracellular Space
- presynaptic membrane
- synapse
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ntng2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- axonogenesis
- regulation of synaptic transmission
- regulation of neuron projection development
- regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- presynaptic active zone membrane
- extracellular region
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding