Lrrc4 Gene Summary [Rat]
Predicted to be involved in modulation of chemical synaptic transmission and synapse organization. Predicted to act upstream of or within synapse organization. Predicted to be located in neuron spine and postsynaptic membrane. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and plasma membrane. Predicted to be integral component of postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | Lrrc4 |
| Official Name | leucine rich repeat containing 4 [Source:RGD Symbol;Acc:1560026] |
| Ensembl ID | ENSRNOG00000008098 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing 4 |
| Synonyms | BAG, leucine rich repeat containing 4, MBAG1, NAG14, NGL-2, NLG-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lrrc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- immunoglobulin domain
- Immunoglobulin I-set domain
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
- cytoplasmic domain
- Immunoglobulin like
- Leucine rich repeat N-terminal domain
- PDZ binding motif
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- rosacea
- hyperactive behavior
regulated by
- motor neurons
- LMK-235
- 9,10-dimethyl-1,2-benzanthracene
- NTNG2
- formestane
- propylthiouracil
role in cell
- expression in
- proliferation
- phosphorylation in
- activation in
- synaptic transmission
- adhesion
- differentiation
- development
- assembly
- stabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cell surface
- cellular membrane
- postsynaptic membrane
- synaptic membrane
- dendritic spines
- neurites
- synapse
- axons
- excitatory synapses
- dendritic branches
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lrrc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- postsynaptic density protein 95 clustering
- regulation of synaptic transmission
Cellular Component
Where in the cell the gene product is active
- excitatory synapse
- dendritic spine
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding