NTNG2 Gene Summary [Human]
Predicted to be involved in several processes, including basement membrane assembly; cell morphogenesis involved in differentiation; and regulation of cell projection organization. Located in Flemming body; intercellular bridge; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NTNG2 |
| Official Name | netrin G2 [Source:HGNC Symbol;Acc:HGNC:14288] |
| Ensembl ID | ENSG00000196358 |
| Bio databases IDs | |
| Aliases | netrin G2, Netrin-G2 |
| Synonyms | 2610016D08RIK, bA479K20.1, Laminet2, LHLL9381, Lmnt2, NEDBASH, NetrinG2, NTNG1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NTNG2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Laminin-type epidermal growth factor-like domai
- Laminin N-terminal (Domain VI)
- protein binding
- EGF_CA
- Laminin EGF domain
Pathways
Biological processes and signaling networks where the NTNG2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder with behavioral abnormalities, absent speech and hypotonia
- androgenic alopecia
- Crohn disease
- neurodevelopmental disorder
- schizophrenia
- COVID-19
- systemic lupus erythematosus
- carcinoma in situ
- epithelial cancer in situ
- Bell palsy
regulates
role in cell
- adhesion
- assembly
- development
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cell surface
- Extracellular Space
- presynaptic membrane
- synapse
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NTNG2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- axonogenesis
- regulation of synaptic transmission
- regulation of neuron projection development
- regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- presynaptic active zone membrane
- extracellular region
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding