Sec61a1 Gene Summary [Rat]
Predicted to enable several functions, including calcium channel activity; protein transmembrane transporter activity; and ribosome binding activity. Involved in response to type II interferon. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of Sec61 translocon complex. Human ortholog(s) of this gene implicated in autosomal dominant tubulointerstitial kidney disease; common variable immunodeficiency; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sec61a1 |
| Official Name | Sec61 translocon alpha 1 subunit [Source:RGD Symbol;Acc:68321] |
| Ensembl ID | ENSRNOG00000013743 |
| Bio databases IDs | |
| Aliases | Sec61 translocon alpha 1 subunit |
| Synonyms | ADTKD5, CVID15, HNFJ4, HSEC61, rSEC61alpha p, SEC61, SEC61A, SEC61 alpha1, SEC61 translocon subunit alpha 1, SEC61 translocon subunit α 1, Sec61 α |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sec61a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Plug domain of Sec61p
- calcium channel
- ribosome binding
- SecY
- protein binding
- transporter
- preprotein translocase, SecY subunit
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal dominant severe congenital neutropenia type 11
- familial juvenile hyperuricemic nephropathy type 4
- common variable immunodeficiency type 15
- prostate cancer
role in cell
- growth
- organization
- splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- endoplasmic reticulum membrane
- rough endoplasmatic reticulum
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sec61a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SRP-dependent cotranslational protein targeting to membrane, translocation
- cotranslational protein targeting to membrane
- SRP-dependent cotranslational protein targeting to membrane
- calcium ion transmembrane transport
- protein targeting to ER
- protein insertion into ER membrane
- posttranslational protein targeting to membrane, translocation
- endoplasmic reticulum organization
- pronephric nephron development
- posttranslational protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- Sec61 translocon complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein transmembrane transporter activity
- calcium channel activity
- ribosome binding
- signal sequence binding