Cers3 Gene Summary [Rat]
Predicted to enable sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process and cornification. Predicted to act upstream of or within sphingolipid biosynthetic process. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 9. Orthologous to human CERS3 (ceramide synthase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cers3 |
| Official Name | ceramide synthase 3 [Source:RGD Symbol;Acc:1564356] |
| Ensembl ID | ENSRNOG00000013823 |
| Bio databases IDs | |
| Aliases | ceramide synthase 3 |
| Synonyms | 4930550L11RIK, ARCI9, ceramide synthase 3, Gm488, LASS3, mCerS3, RGD1564356, T3L |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cers3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TLC domain
- transcription regulator
- sphingosine N-acyltransferase
- protein binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive congenital ichthyosis type 9
- lamellar ichthyosis
- pathologic myopia
- psoriasis
- desquamation
- ichthyosis
- hyperkeratosis
- skin barrier defect
- autosomal recessive ichthyosis
- infection by fungus
role in cell
- differentiation
- expression in
- formation
- function
- synthesis in
- abnormal morphology
- condensation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cers3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinocyte differentiation
- epidermis development
- ceramide biosynthetic process
- cornification
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- sphingosine N-acyltransferase activity