Hmgcs1 Gene Summary [Rat]
Enables hydroxymethylglutaryl-CoA synthase activity; isomerase activity; and organic acid binding activity. Involved in several processes, including cellular response to cholesterol; cellular response to follicle-stimulating hormone stimulus; and response to vitamin E. Predicted to be located in cytoplasm. Biomarker of obesity. Orthologous to human HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmgcs1 |
| Official Name | 3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:RGD Symbol;Acc:70970] |
| Ensembl ID | ENSRNOG00000016552 |
| Bio databases IDs | |
| Aliases | 3-hydroxy-3-methylglutaryl-CoA synthase 1 |
| Synonyms | 3-hydroxy-3-methylglutaryl-CoA synthase 1, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1, B130032C06Rik, HMGCS, HMGS, Hydroxymethylglutaryl-CoA synthase, cytoplasmic, MGC36662 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hmgcs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cond_enzymes
- 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade
- binding protein
- 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
- hydroxymethylglutaryl-CoA synthase
- protein homodimerization
- isomerase
- enzyme
- protein binding
- Hydroxymethylglutaryl-coenzyme A synthase C terminal
Pathways
Biological processes and signaling networks where the Hmgcs1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- organismal death
- rigid spine syndrome
- preeclampsia
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
role in cell
- expression in
- proliferation
- morphology
- cell death
- invasion by
- survival
- growth
- molecular cleavage in
- bacterial burden
- regrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hmgcs1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- farnesyl diphosphate biosynthetic process, mevalonate pathway
- acetyl-CoA metabolic process
- lipid metabolic process
- cholesterol biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- hydroxymethylglutaryl-CoA synthase activity