Arfrp1 Gene Summary [Rat]
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in protein localization to Golgi apparatus; protein transport; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within gastrulation. Predicted to be located in membrane and trans-Golgi network. Predicted to be active in Golgi apparatus. Orthologous to human ARFRP1 (ARF related protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arfrp1 |
| Official Name | ADP-ribosylation factor related protein 1 [Source:RGD Symbol;Acc:621683] |
| Ensembl ID | ENSRNOG00000013992 |
| Bio databases IDs | |
| Aliases | ADP-ribosylation factor related protein 1 |
| Synonyms | 1500006I01Rik, ARF related protein 1, ARL18, ARP, Arp1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arfrp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sar1p-like members of the Ras-family of small GTPases
- ADP-ribosylation factor family
- Ras family
- 50S ribosome-binding GTPase
- GTPase
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- growth failure
- lipodystrophy
- diverticular disease
- clear-cell ovarian carcinoma
- clear cell ovarian cancer
- breast cancer metastatic to brain
- brain metastasis
- metastatic breast cancer
role in cell
- accumulation in
- binding in
- aggregation
- formation
- size
- formation in
- structural alteration in
- lipolysis in
- structural alteration
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- cytosol
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arfrp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization in Golgi apparatus
- signal transduction
- Golgi to plasma membrane protein transport
- retrograde transport, endosome to Golgi
- intracellular protein transport
- gastrulation
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- membrane
- cytosol
- Golgi apparatus
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity