Apoc3 Gene Summary [Rat]
Predicted to enable high-density lipoprotein particle receptor binding activity; lipase inhibitor activity; and phospholipid binding activity. Involved in several processes, including lipoprotein transport; negative regulation of oxidative phosphorylation; and positive regulation of triglyceride biosynthetic process. Located in extracellular space. Used to study hyperthyroidism; hypothyroidism; and type 1 diabetes mellitus. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in several diseases, including apolipoprotein C-III deficiency; chronic kidney disease; familial hyperlipidemia (multiple); glucose metabolism disease (multiple); and hepatocellular carcinoma. Orthologous to human APOC3 (apolipoprotein C3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apoc3 |
| Official Name | apolipoprotein C3 [Source:RGD Symbol;Acc:2136] |
| Ensembl ID | ENSRNOG00000047503 |
| Bio databases IDs | |
| Aliases | apolipoprotein C3 |
| Synonyms | APOCIII, apolipoprotein C3, apolipoprotein C-III |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Apoc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- phospholipid binding
- enzyme inhibitor activity
- Apolipoprotein CIII (Apo-CIII)
- protein binding
- enzyme regulator activity
- receptor binding
- transporter
Pathways
Biological processes and signaling networks where the Apoc3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- insulin resistance
- obesity
- familial partial lipodystrophy
- hyperalphalipoproteinemia type 2
- insulin-dependent diabetes mellitus
- non-insulin-dependent diabetes mellitus
- coronary artery disease
- liver cancer
- hepatocellular carcinoma
role in cell
- apoptosis
- expression in
- production in
- activation in
- cell death
- phosphorylation in
- accumulation in
- function
- response by
- efflux in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- cellular membrane
- cytosol
- Golgi membrane
- early endosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Apoc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- high-density lipoprotein particle remodeling
- triglyceride metabolic process
- lipoprotein metabolic process
- cholesterol homeostasis
- negative regulation of cholesterol import
- negative regulation of very-low-density lipoprotein particle clearance
- negative regulation of lipoprotein lipase activity
- reverse cholesterol transport
- negative regulation of triglyceride catabolic process
- negative regulation of receptor-mediated endocytosis
- triglyceride homeostasis
- negative regulation of lipid catabolic process
- regulation of Cdc42 protein signal transduction
- negative regulation of fatty acid biosynthetic process
- chylomicron remnant clearance
- G-protein coupled receptor signaling pathway
- negative regulation of lipid metabolic process
- negative regulation of low-density lipoprotein particle clearance
- negative regulation of very-low-density lipoprotein particle remodeling
- very-low-density lipoprotein particle assembly
- negative regulation of high-density lipoprotein particle clearance
- cholesterol efflux
- triglyceride catabolic process
- phospholipid efflux
Cellular Component
Where in the cell the gene product is active
- very-low-density lipoprotein particle
- early endosome
- extracellular space
- chylomicron
- extracellular vesicular exosome
- intermediate-density lipoprotein particle
- spherical high-density lipoprotein particle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- cholesterol binding
- lipase inhibitor activity
- high-density lipoprotein particle receptor binding
- phospholipid binding
- enzyme regulator activity