Arhgef4 Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Predicted to be involved in filopodium assembly and lamellipodium assembly. Predicted to be located in cytoplasm. Orthologous to human ARHGEF4 (Rho guanine nucleotide exchange factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgef4 |
| Official Name | Rho guanine nucleotide exchange factor 4 [Source:RGD Symbol;Acc:1586179] |
| Ensembl ID | ENSRNOG00000014035 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor 4 |
| Synonyms | 9330140K16RIK, ASEF, ASEF1, C230030N03Rik, GEF4, Rho guanine nucleotide exchange factor 4, SMIM39, STM6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arhgef4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- guanyl-nucleotide exchange factor
- PH domain
- APC binding domain
- protein domain specific binding
- protein binding
- Pleckstrin homology-like domain
- RhoGEF domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Arhgef4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteoarthropathy
- progression free survival
role in cell
- activation in
- binding in
- accumulation in
- adhesion
- migration
- formation
- ruffling
- size
- fragmentation
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- membrane ruffles
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arhgef4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- lamellipodium assembly
- filopodium assembly
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- ruffle membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- guanyl-nucleotide exchange factor activity